Desplats Lab at UC San Diego
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2014

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  3. 2014
  • By pendari1060
  • August 19, 2021
  • 0

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E. J Biol Chem. 2014 Jun 20;289(25):17917-31. PMID: 24825898

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E. J Biol Chem. 2014 Jun 20;289(25):17917-31. PMID: 24825898
  • By pendari1060
  • August 19, 2021
  • 0

Hippocampal neuronal cells that accumulate a-synuclein fragments are more vulnerable to Aß oligomer toxicity via mGluR5–implications for dementia with Lewy bodies. Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. Mol Neurodegener. 2014 May 19;9:18. PMID: 24885390

Hippocampal neuronal cells that accumulate a-synuclein fragments are more vulnerable to Aß oligomer toxicity via mGluR5–implications for dementia with Lewy bodies. Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. Mol Neurodegener. 2014 May 19;9:18. PMID: 24885390
  • By pendari1060
  • August 19, 2021
  • 0

ESCRT-mediated uptake and degradation of brain-targeted a-synuclein single chain antibody attenuates neuronal degeneration in vivo. Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. Mol Ther. 2014 Oct;22(10):1753-67. PMID: 25008355

ESCRT-mediated uptake and degradation of brain-targeted a-synuclein single chain antibody attenuates neuronal degeneration in vivo. Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. Mol Ther. 2014 Oct;22(10):1753-67. PMID: 25008355
  • By pendari1060
  • August 19, 2021
  • 0

Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, Smith D, Masliah E, Grant I. PLoS One. 2014 Jul 23;9(7):e102555. PMID: 25054922

Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, Smith D, Masliah E, Grant I. PLoS One. 2014 Jul 23;9(7):e102555. PMID: 25054922
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Research in our lab is aimed at elucidating the dynamic mechanisms of DNA methylation, which might contribute to onset and progression of the most prevalent neurodegenerative diseases of the elderly, Parkinson’s and Alzheimer’s.

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UCSD School of Medicine Department of Neurosciences MTF Room 344 9500 Gilman Drive Mail code 0624 La Jolla
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